Short peptides self-assemble to produce catalytic amyloids

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Short peptides self-assemble to produce catalytic amyloids

Enzymes fold into unique three-dimensional structures, which underlie their remarkable catalytic properties. The requirement to adopt a stable, folded conformation is likely to contribute to their relatively large size (>10,000 Da). However, much shorter peptides can achieve well-defined conformations through the formation of amyloid fibrils. To test whether short amyloid-forming peptides might...

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ژورنال

عنوان ژورنال: Nature Chemistry

سال: 2014

ISSN: 1755-4330,1755-4349

DOI: 10.1038/nchem.1894